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The pre-specified renal outcomes included incident or worsening nephropathy (progression to macroalbuminuria, doubling of the serum creatinine level, initiation of renal-replacement therapy, or death from renal disease) and incident albuminuria (34)

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mGFR and effective renal plasma flow were determined by clearances of Iohexol and para-amminohippuric acid, respectively

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GLP-1 is an incretin hormone, meaning it helps the body respond to meals