oral semaglutide hims compounded Novo abruptly ends obesity drug

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So we're excited to be able to reengage with Novo about the oral pill that is hopefully to be FDA approved as well as the commercial dosing," Andrew Dudum, co-founder and CEO of Hims & Hers, told investors during the company's third-quarter earnings call Monday

Evidence supporting a direct, weight-independent anti-inflammatory mechanism: CRP reductions in clinical trials appear only partly explained by weight loss (6) Anti-inflammatory effects are observed in cell culture and animal studies where weight loss is not a factor (8) Some patients show inflammatory marker improvement before significant weight loss occurs GLP-1 receptors on immune cells provide a clear mechanistic pathway independent of adipose tissue reduction The most likely reality is that semaglutide reduces inflammation through both pathways simultaneously direct immune modulation plus indirect effects from visceral fat reduction and metabolic improvement

Acknowledgements The author thanks Morten Donsmark and Tine Bkdal (both Novo Nordisk A/S, Sborg, Denmark), and Kazushiro Fujiwara, and Eirik Quamme Bergan (both Novo Nordisk Pharma Ltd, Tokyo, Japan) for reviewing the manuscript, and to Andy Bond of Spirit Medical Communications Group Ltd for medical writing and editorial assistance (funded by Novo Nordisk A/S, Sborg, Denmark)