glp 1 receptor agonist structure Cryo-EM of the activated GLP-1 in complex with a G protein Crystal structure of the GLP-1

Cognitive Aging Research: Studies examining age-related cognitive decline, brain metabolism changes, and potential metabolic interventions

Cruelty-Free | Not tested on animals | Safe for face & body care routines

Hair, Skin & Nails

Mutations in SLC25A19 cause Amish lethal microcephaly (MCPHA) and thiamine metabolism dysfunction syndrome 4

MC1R is expressed on keratinocytes, fibroblasts, dendritic cells, mast cells, and other immune cells in the skin , and MT-1-mediated MC1R activation produces anti-inflammatory effects in these cell types through cAMP-mediated suppression of NF-B activation, reduction of pro-inflammatory cytokine production including TNF-alpha and IL-6, inhibition of reactive oxygen species generation, and modulation of dendritic cell maturation and antigen presentation

Studies demonstrated that type I interferon enhances manganese-induced ferroptosis sensitivity by downregulating mitochondrial DHODH, elucidating the underlying molecular mechanism