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Acknowledgements The authors acknowledge the support of NIH grants DK126715 (R.D.C.), F32HD095620 (P.S.), K99DK127065 (P.S.), R00 DK127065 (P.S.), Brain and Behaviour Research Foundation Young Investigator Award (P.S.), Foundation for Prader Willi Research (P.S.), Courage Therapeutics (R.D.C.) and The Klarman Family Foundation (R.D.C.)