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Tirzepatide (MOUNJARO) Pronounced: tir ZEP a tide / mown JAHR OH Mnemonic: Tear zeppelin (over) Mount (Kiliman)jaro Year of release: 2022 Cost: $1060 / mo FDA-approved for: Type 2 diabetes Mechanism: dual GLP-1/GIP receptor agonist Available doses: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg (weekly subcutaneous injection) Dynamic interactions: Glucose lowering Kinetic interactions: Delayed gastric emptying, otherwise none significant in a bubble Tirzepatide (Mounjaro) is the first twincretin for type 2 diabetes
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The graphical (Supplementary Figure 2) and analytical evaluation (Egger's asymmetry test) do not suggest publication bias (p=0.811)
The trial met its primary endpoint, demonstrating statistically significant and superior weight loss with CagriSema versus placebo
Phase IIa trials focus on proof of concept (POC) and short-term safety
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