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Some signs that you should extend your current dose period before escalating include diarrhea that occurs more than 3 times daily, diarrhea that has not improved after 3 weeks at the current dose, significant dehydration symptoms (dark urine, dizziness, dry mouth), or diarrhea that is interfering with daily activities or work

They are clinical landmines

To put that in practical terms, a person starting at 231 pounds would lose approximately 56 pounds

p-GSK-3, hosphor glycogen synthase kinase 3

8 Blood glucose monitoring is required in these patients and reductions in sulfonylurea or insulin dosing may be necessary (see: Prescribing empagliflozin for guidance on dose adjustments)

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