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Regular check-ins follow, with many follow-ups available virtually for your convenience

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According to the two-year STEP 5 trial published in Nature Medicine, 2022, semaglutide produced substantial, sustained weight loss of about 15.2 percent over 104 weeks, evidence that supports staying on a well-managed dose long term rather than treating GLP-1 therapy as a brief intervention

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Finding support Speak to your GP or epilepsy specialist if youre experiencing persistent low mood, anxiety, or difficulty coping Regular physical activity has evidence for improving both mood and quality of life in people with epilepsy 10 Cognitive behavioural therapy (CBT) has evidence for managing anxiety and depression in chronic health conditions Epilepsy support organisations like the Epilepsy Society and Epilepsy Action offer peer support and helplines If youre starting Wegovy, be aware that the early weeks of dose escalation can be physically uncomfortable, which may temporarily affect your mood If you think your AED is affecting your mood, discuss this with your neurologist rather than stopping the medication When to speak to your GP Contact your GP, prescriber, or epilepsy specialist if you experience any of the following after starting Wegovy: Any change in seizure frequency or severity New or worsening side effects from your anti-epileptic medication (dizziness, double vision, unsteadiness, skin rash) Persistent nausea or vomiting that could affect AED absorption Significant weight loss (more than 1 kg per week over several weeks), as this may require AED dose adjustment If you take lamotrigine, report any unusual symptoms promptly as blood levels may need checking Significant mood changes or worsening mental health symptoms Signs of dehydration from persistent vomiting or diarrhoea (dizziness, dark urine, extreme thirst) Frequently asked questions Is Wegovy safe for people with epilepsy