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and is expected to rise with an aging demographic and increasing prevalence of diabetes, the leading cause of CKD and kidney failure

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While glucagon receptor agonism alone could raise blood glucose levels, this effect is counterbalanced by the simultaneous GLP-1 and GIP receptor activation, which enhance insulin secretion and glucose disposal

J Epidemiol Community Health 65(Suppl 2):A12A12 Rosner MH, Okusa MD (2006) Acute kidney injury associated with cardiac surgery