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Telomerase normally helps offset that loss, as outlined in this reference on telomerase and telomere maintenance

The mechanism of action for AOD 9604 involves stimulating fat breakdown and fat oxidation in adipose tissue, supporting research into its potential as a treatment for obesity and metabolic disorders

21 CFR Parts 210-211

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However, if you have insulin resistance or diabetes, you should still monitor blood sugar closely and consult a healthcare provider before use