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An important early example investigated the effect of both knockout and transgenic uricase in mice receiving intracerebral 6-hydroxydopamine administration, which leads to dopaminergic neurodegeneration 33

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[15] [16] Tests may include full blood count, serum B12 levels, anti-intrinsic factor antibodies (to diagnose pernicious anaemia), and sometimes methylmalonic acid or homocysteine levels when the diagnosis is uncertain

M., Van Eyk, J

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Cells were centrifuged and the supernatant collected