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NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA)

Most people can prevent it by eating enough meat, poultry, seafood, dairy products, and eggs

These are associations rather than proof that altering NNMT activity reverses metabolic changes, but they motivate continued research into NNMT inhibitors in metabolic models

IV infusions also allow nutrient customization

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