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We performed separate analyses based on type of comparator (placebo, GLP-1 RA or basal insulin) and subgroup analyses based on tirzepatide maintenance dose (5, 10 or 15 mg once-weekly)
Based on the present steady-state data, we compared the developed population PK model to a one-compartment PK model similar to the one estimated in the phase 3 analysis [6] with almost identical results
Currently, an estimated 40% of adults in the United States are living with obesity, a chronic health condition that can increase the likelihood of type 2 diabetes, high blood pressure, heart disease, stroke and even certain cancers
These include increased exercise and a low-calorie and low-fat diet
Consequently, GIP receptor antagonism was proposed as a potential strategy for treating obesity-related diabetes (73)
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