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Patients usually begin observing visible weight reduction within a couple of weeks after initiating their therapy

For the IL-17A/IL-22 fusion, significant protein engineering was required to obtain a dual activity profile in in vitro assays and to limit the peptide degradation during production, a phenomenon frequently observed for peptide fusion molecules expressed in transfected cells 30

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In some analyses, early initiation is associated not merely with neutral cardiovascular outcomes but with active cardiovascular benefit, a finding that aligns with the known role of estrogen in maintaining vascular elasticity, endothelial function, and lipid metabolism [12]