All of them could still fail in later trials, which is normal: most drugs that look promising in Phase 2 never reach market
For the surgical procedure, rats were anesthetized using ketamine (70 mg/kg, intramuscular (I.M.)) and xylazine (8 mg/kg, I.M.) (Salazar et al
Side effects are usually mild but can include temporary discomfort at the injection site, redness, or slight swelling
As a result, informed comparison matters
Drugs targeting GLP-1R have been used as weight loss and anti-diabetic glucose-lowering therapies (Heppner and Perez-Tilve, 2015)
If any reactions occur, discontinue use of dietary supplement and consult your doctor