TB-500 is a synthetic peptide based on the active region of Thymosin Beta-4 (T4) , a naturally occurring 43-amino-acid protein that is among the most abundant actin-binding molecules in mammalian cells
If effect is too drastic, reduce to 3x/week
In vivo evidence corroborates this finding, such that mice with an ApoE4 background display an over 10x higher HSV-1 load in the brain compared to mice with an ApoE3 background, strikingly with viral DNA also being detected in the ovaries, spinal cord and trigeminal ganglia in infected ApoE4 mice (Flowers and Rebeck, 2020), thus offering less overall antimicrobial protection, but also mechanistically as ApoE4 prevents HSV-1 cellular attachment but crucially not viral entry or replication, and can also be incorporated into the HSV-1 virion that can enhance release from the cell (Feng et al., 2023), which would be an issue for viral AD
Glutathione is a tripeptidea small protein moleculemade up of three specific amino acids: cysteine, glutamic acid, and glycine
The Gap Between Animal Promise and Clinical Evidence The disconnect between BPC-157's strong animal hepatoprotective data and the absence of human liver-specific trials represents one of the widest evidence gaps in peptide therapeutics
Many of our patients benefit from 50gm but some patients may have to increase their dosage based on current state of disease