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A1C dropped by an average of 1.9% and 2.2% with the low and high doses of orforglipron, compared with 1.1% and 1.4% with semaglutide

Visible changes in muscle tone and fat loss typically appear between weeks 6 and 12 of a consistent protocol

Additional authors include: Donna H

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Vomiting affected 31% of high-dose participants, while diarrhea occurred in 23% of patients

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