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The inability to maintain reduced glutathione in RBCs leads to increased accumulation of peroxides, predominantly H 2 O 2 , that in turn results in a weakening of the cell wall as a result of membrane lipid peroxidation resulting in concomitant hemolysis

In addition to elevated CRP, IL-6, and TNF-, shift workers show altered immune profiles such as a reduced CD4 + /CD8 + T-cell ratio, increased monocyte counts, and impaired NK cell cytotoxicity

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doi: 10.1038/s41579-021-00511-0 176 JacksonB

PMID 31305876