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Assessing growth and response to therapy in murine tumor models

BisanzJEEnosMKPray GodGSeneySMacklaimJMChiltonSet al (2015)

When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2

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