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In the Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron produced mean body weight reductions of 7.5% (6 mg), 8.4% (12 mg), and 11.2% (36 mg) at 72 weeks, compared with 2.1% for placebo

Localized wound healing studies typically use every-48-hour dosing for 1421 days, while systemic collagen synthesis protocols use every-72-hour dosing for 2128 days

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Troubleshooting: Clumps, Cloudiness, Particles Clumpy or slow to dissolve: give it more time and keep swirling gently resist the urge to shake

Optimal needling protocols Needle depth affects results significantly