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Complementary approaches such as siRNA-mediated NNMT knockdown, shRNA-mediated knockdown, CRISPR-based perturbation, or comparison with a structurally distinct NNMT inhibitor can help determine whether an observed phenotype follows NNMT biology rather than an unrelated chemical or solvent-associated effect

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* Seiwerth S, Rucman R, Drmic T, Kozina B, Sikiri P

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