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A GLP1 prescription could indicate: Well-controlled type 2 diabetes Severe obesity under active treatment Metabolic dysfunction associated steatohepatitis (MASH) Obstructive sleep apnea Elevated cardiovascular risk Chronic kidney disease Clinically, those are very different scenarios with very different mortality implications

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Many executives also believe that the FDA's announcement is not the end of the story and expect regulatory and legal action

In 2024, Sun and colleagues investigated GLP-1 receptor agonists in a DSS-colitis model