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Mechanisms of platinum resistance include, but not limited to, reduced accumulation of drugs due to impaired influx or potent efflux/secretion mechanisms, accumulation of reactive oxygen species (ROS) and simultaneous detoxification by antioxidants, elevated levels of DNA damage repair mechanisms, changes in membrane protein trafficking, aberrant protein and gene expressions altering drug transport and uptake, as well as pathways such as those hindering apoptosis and inducing EMT in response to chemotherapy treatment in surviving cells [29]
It is highly desirable to integrate different therapeutic methods together to achieve multimodal synergistic therapy for cancer treatment
Contenidos Orlistat cuesta aproximadamente 317 pesos mexicanos en farmacias o supermercados fsicos, as como en algunas tiendas en lnea
Koo et al., 2023
Thus, people who do not consume food of animal origin are at a higher risk of suffering from anaemia
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