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In the liver, the 25-hydroxylase enzymes (CYP2R1 and CYP27A1) convert inactive cholecalciferol to 25(OH)VD 3 (calcidiol) by carbon 25 hydroxylation 14

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Weight regain is common for patients who stop taking the medications, and benefits often fade within two years, early research has found

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European Journal of Nutrition , 54(2), 251263.