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Malignant AN is a rare paraneoplastic syndrome likely due to the release of stimulatory growth factors by tumour cells and is typically associated with gastrointestinal malignancies, especially gastric adenocarcinoma (60%)
however, dedicated cardiovascular outcome trial (CVOT) data have not yet been published, and cardiovascular benefit has not been demonstrated Phase 3 trials are ongoing
The skin appears dry, discolored, leathery, and wrinkled with repeated sun damage
With three options on the table, the right choice usually comes down to two questions: how many times will you draw from this vial, and does the substance you're reconstituting tolerate a preservative
doi: 10.1038/ncomms6418 191 XiaoYLiangLHuangMQiuQZengSShiMet al