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Addressing gallbladder risks in patients on GLP-1RAs The increased risk of gallbladder disease associated with GLP-1RAs has important clinical implications that require careful consideration in the management of patients undergoing this therapy (Figure 4)

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These early studies confirmed the once-weekly dosing feasibility and identified the gastrointestinal side effectsprimarily nausea, vomiting, and diarrheathat would become characteristic of GLP-1 receptor agonist therapy