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GLP-1 receptor agonists originally developed for type 2 diabetes are now recognized for benefits extending far beyond weight reduction

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Gene expression changes also involved pathways linked to autoimmune diseases, cancer, and major depressive disorder, indicating that even brief circadian disruption can trigger systemic inflammatory responses with potential long-term health consequences 146

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Orforglipron and the Next Wave of Oral GLP-1s While injectable GLP-1s dominate the market, patient compliance can sometimes wane due to injection fatigue

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