It is a triple glucoincretin receptor agonist, targeting glucagon, GLP-1, and GIP receptors that all primarily regulate appetite, glucose, and fat metabolism
Paladugu L, Gharaibeh A, Kolli N, Learman C, Hall TC, Li L, et al
Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial
Nasal spray offers a middle ground with moderate bioavailability and no needles, though higher doses are required
Plenty of things can cause nausea
Before adjusting your semaglutide regimen, have your provider order basic labs: thyroid panel, fasting glucose, HbA1c, lipids, and cortisol