Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle
Neuropsychopharmacology 43 , 11461155 (2017)
toxicity risk is lower than with agents that increase digoxin levels, but bradycardia monitoring remains appropriate
Pharmacological controls: for IGF-1 LR3 wortmannin (PI3K block, 100 nM), rapamycin (mTORC1 block, 20 nM), PD98059 (MEK-ERK block, 20 M)
PubMed laboratory research record [PMID: 40521912] PubMed record related to this compound for laboratory literature review
However, dose increases should not be the first intervention for a stall