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This is the dual-agonist component that tirzepatide shares with retatrutide

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Last reviewed: May 31, 2026 Last updated: May 31, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

[5] Sustained NO Production - L-citrulline creates a longer-lasting elevation of plasma arginine levels compared to direct L-arginine supplementation, providing extended NO production benefits

Yang L, Wang Z, Zou C, Mi Y, Tang H, Wu X (2020) Ubiquitin-specific protease 49 attenuates IL-1-induced rat primary chondrocyte apoptosis by facilitating Axin deubiquitination and subsequent Wnt/-catenin signaling cascade inhibition