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106-OR: A First-in-Human Single Ascending Dose Study of Oxyntomodulin Analog LY3305677 in Healthy Subjects
Dysgeusia (a taste disorder)
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Three recurrent failure modes explain the historical record: (1) exposure infeasibility when low bioavailability combines with short elimination half-life, preventing accumulation regardless of formulation sophistication
It needs to be broken down, mixed with stomach acids, bind with intrinsic factor, and then be absorbed in the small intestine
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