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208 Insulin-like growth factor binding proteins 1 and 2 (IGFBP1 and IGFBP2, respectively) are the most abundant circulating IGFBPs and have lower concentrations in adipose tissue in obese patients, in addition to being negatively associated with hyperinsulinemia and IR

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Milaneschi Y, Lamers F, Berk M, Penninx BWJH

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"Anecdotally, what I'm also seeing from my patients they're lighter, they feel better, they're more motivated to go to the gym, they're motivated to exercise, they're more motivated to [adopt] a healthier lifestyle, because they see what it could feel like lighter," he told Fox News Digital

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The public comment period closes June 29, 2026

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J Mol Neurosci 66(2):197206

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