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We therefore postulated that IGF-1R mAbs could represent a viable therapeutic tool to target IGF-1 action, and potentially mimic the beneficial effects associated with diminished IGF-1 signaling observed in animal models

Resilience is determined by the robustness of individual pathways, the efficiency of stress sensing and signaling coordination, and the ability of parallel systems to compensate when one mechanism becomes overwhelmed

Nassuato G, Iemmolo RM, Strazzabosco M, Lirussi F, Deana R, Francesconi MA,

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10.1016/j.phymed.2020.153218 213 SainiS.AroraS.MajidS.ShahryariV.ChenY.DengG.et al (2011)

Reduced folate/ThDP exchanger SLC19A1, demonstrating decreased transcript levels 1 month after the bypass, shares the cluster (3 g) with mitochondrial ThDP transporter SLC25A19, ThTPase and BCKDHA (Figure 5A)