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& Tsokos, G

1 In OASIS 4, common adverse reactions were similar to those previously seen in clinical trials with Wegovy (semaglutide) injection 2.4 mg, including nausea, diarrhea, and vomiting

A: Some individuals may experience nausea, mild pain at the injection site, or in rare cases, an allergic reaction

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Concomitantly with the development of resistance the up-regulation of a hydrogen-peroxide inducible GST was observed that might contribute to the elimination of cytotoxic reactive metabolites containing an electrophilic moiety (Shibu et al., 2012)

Under such pressure, Novo Nordisk needs to achieve a new breakthrough in oral Semaglutide tablets to break this deadlock