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During the ischemic phase, the rapid depletion of ATP leads to a significant decrease in mitochondrial membrane potential, which in turn triggers electron transport chain dysfunction

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However, it is unclear why genistein upregulates the levels of Nrf2 in the myocardium

doi: 10.1016/j.bcp.2024.116102 60 XiaZWeiZLiXLiuYGuXTongJet al

However, the exact nature of these benefits will depend on how it is applied