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Moreover, ALT-801 is a balanced dual receptor agonist 19,20 with closely matched potencies at the GLP-1R and GCGR (39 pM and 42 pM, respectively 20 ), as distinguished from the dual agonists cotadutide 42 and BI456906 43 , which appear to be biased 5:1 and 7.5:1, respectively, toward GLP-1R activation
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The per-compound and analog data support the following framing: During retatrutide titration alone (months 0-3): Standard retatrutide GI tolerability profile
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10.1002/emmm.201302451 336
