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Physical Dependence and Addiction to Benzodiazepines Physical dependence on benzodiazepines can develop rapidly often within 2-4 weeks of regular use, even when taking prescribed doses

Several preclinical and clinical studies showcase these effects, which include: Erectile Dysfunction (ED): The effects of MT-II on males have been studied clinically

Peak effect: 13 hours for most medications in this class

If its been more than 5 days, skip the missed dose and wait until your next scheduled dose

John Kirwan, Executive Director of Pennington Biomedical

Gastrointestinal side effects, if they occur, are most common during this initial phase