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Published case reports of GLP-1-associated anaphylaxis confirm that cross-reactivity between different GLP-1 agents can occur, meaning a person allergic to exenatide might also react to lixisenatide but tolerate liraglutide or semaglutide, which have different molecular structures

HMOX activity was determined by measurements of CO production using gas chromatography with a reduction gas analyzer (Peak Instruments, Menlo Park, CA, USA) as described previously.21 HMOX activity was calculated as pmol CO/h/mg of protein

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This is supported by the peptides association with a high molecular weight complex of around 150 kDa

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