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The discovery of GIP, a potent stimulator of insulin secretion, laid the foundation for the successful mapping of the proglucagon gene and the discovery of the glucagon-like polypeptides GLP-1 and GLP-2
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Then came a revelation
Danne T, Cariou B, Banks P et al (2018) HbA 1c and hypoglycemia reductions at 24 and 52 weeks with sotagliflozin in combination with insulin in adults with type 1 diabetes: the European inTandem2 study
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Retatrutide (LY3437943) is a peptide developed by Eli Lilly that acts on three different metabolic receptors simultaneously: GLP-1 receptor GIP receptor Glucagon receptor This makes Retatrutide the first triple-agonist peptide to reach advanced Phase 3 clinical development
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