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The detrimental effects of low-temperature preservation of ovarian tissue encompass ROS generation, DNA fragmentation, and caspase activation, which may result in damage to granulosa and stromal cells, oocyte degeneration, and follicular attrition
Following IV administration, the estimated half-life of methylene blue is 5-6.5 hours
Nature 590, 140145
Our plan is to conduct future human trials to test whether GSH supplements along with controlled iron chelation have similar affects in human counterparts
[4] Uribe PM, Kawas LH, Harding JW, Coffin AB
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