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the expression levels of the mutant constructs did not significantly differ from Go-Nt 7 (Supplementary Fig

Authors concluded that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and subsequently DNA becomes methylated and inaccessible resulting in transcriptional silencing thus demonstrating interplay between histone reprogramming and promoter region methylation (Okino et al., 2007)

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Wu, Y., Tang, L., & Chen, B