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These hormones help regulate appetite, blood sugar, fat metabolism, and energy expenditure, which may allow retatrutide to produce greater weight loss than GLP-1s, Kevin Gendreau, MD, an obesity medicine physician at Signature Healthcare in Massachusetts, told Health

If you plan to discontinue tirzepatide, consider a gradual dose reduction over 8-12 weeks

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(If YES, avoid PT-141)- Has the patient had a recent cardiovascular event

This is because of a hormone called cortisol which is critical for several bodily functions like regulating metabolism