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Liu, L., Su, X., & Quinn, W

Lund PK, et al

We believe in a comprehensive model where the medication supports lifestyle changes

These include anorectic effects driven by previously discussed central modulation of satiety and reward pathways and peripheral activation of vagal afferents, delayed gastric emptying, anti-inflammatory properties, potential impact on energy expenditure and the ability to reduce ghrelin levels, which are inherently elevated in PWS ( 2 to 11.3 kg/m 2 (35), waist circumference reduction from 7 to 8 cm (32, 35), as well as HbA1c reduction from 1.9% to 6.5% (34)

Which, I thought at first, was a bit odd, because if anything, these are the people for whom the drug worked best

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