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While all GLP-1 agonists share some common gastrointestinal effects, the triple agonism of retatrutide introduces glucagon receptor-mediated effects that the others do not produce

Oral GLP-1s offer significant weight loss benefits and blood sugar reduction, but not quite as much as the injections, Tenpas said

These hormones help regulate blood sugar after meals and signal the brain to reduce hunger

Populations receiving GLP-1 RAs may be at a higher risk of colorectal cancer due to multiple factors, such as insulin resistance, chronic inflammation, and obesity

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