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The MHRA's Yellow Card scheme (yellowcard.mhra.gov.uk) has received some reports of anxiety-related symptoms with semaglutide products, though causality has not been definitively established
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Current Therapeutic Research 1989;46(6):1027-1033
10.1007/s00125-022-05730-5 Diabetologia 8 BiesselsG.DespaF
Thyroid function should be checked, especially in women with Hashimoto disease on HRT, as hypothyroidism also causes cold intolerance
Cardiovascular Outcomes Semaglutide has demonstrated cardiovascular benefits, including a reduction in major adverse cardiovascular events (MACE) such as heart attack and stroke in patients with type 2 diabetes at high cardiovascular risk
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