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In this cell type, the effect of GLP-1(2836) on cAMP levels was as robust as that of the adrenergic agonist isoproterenol (IPE) (Figure 3A)
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The presence of multiple GSTs with overlapping functions and substrate specificities might preclude the observation of phenotypic alteration in knockout mutants (Sappl et al., 2009)
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Together, they provide researchers with tools to explore receptor-mediated signaling and downstream experimental readouts in controlled models
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