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The Aib (aminoisobutyric acid) substitution provides both conformational constraint and metabolic stability through its gem-dimethyl alpha carbon, which resists proteolytic attack

this IDS-SR 30 anhedonia subscale has been previously demonstrated to highly correlate with the self-administered and clinician-administered versions of the SHAPS [42] and replicated in other samples [40]

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23 March 2017 Scientific Reports 7: Article number: 40815