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This paradoxical effect results from PCOSs underlying metabolic dysfunction

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Metabolic Adaptation The action the body uses to adjust its energy when reacting to environmental changes, such as weight loss, is called metabolic adaptation

Both cardio (aerobic exercise) and strength training are beneficial, as cardio helps burn fat, while strength training builds muscle mass, which can in turn boost your resting metabolism

GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss