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However, these preclinical findings do not establish safety for use during human pregnancy, as species differences in placental transfer and fetal metabolism may exist

both simply describe why the research protocol looks the way it does

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The Lancet (2023) This Phase 2 trial evaluated CagriSema versus semaglutide alone and cagrilintide alone in 92 adults with type 2 diabetes and overweight or obesity on metformin with or without an SGLT2 inhibitor across 17 US sites