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More studies have shown that long-term HG similarly leads to ROS accumulation in the endoplasmic reticulum and induces ERS (57), interestingly ERS has the potential to contribute to elevated mitochondrial ROS levels, an undesirable interaction that accelerates cell death (46)

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To view a copy of this licence, visit About this article Cite this article Fancello, F., Zara, G., Hatami, F