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Interestingly, suppressing the ER stress pathway PERK-ATF4-CHOP did not affect CHAC1 expression during ferroptosis ( As controlled induction of ferroptosis might prove a promising target for cancer research, various pharmacological substances have been tested for possibly inducing ferroptosis

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Further, a placebo-controlled trial in 152 elderly adults (aged 70-80 years) with mild cognitive impairment reported that B vitamin supplementation (50 mg/day of vitamin B 6 , 5 mg/day of folic acid, and 0.4 mg/day of vitamin B 12 ) for one year did not improve performance on a similar test of verbal fluency (136)

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